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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CHFR
All Species:
6.97
Human Site:
S178
Identified Species:
17.04
UniProt:
Q96EP1
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96EP1
NP_001154816.1
664
73386
S178
C
F
E
E
P
Q
P
S
T
S
T
S
D
L
F
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001083796
668
74184
Q180
Q
V
C
F
E
E
P
Q
P
S
T
S
T
S
D
Dog
Lupus familis
XP_848636
649
71949
S178
E
E
P
Q
P
S
T
S
T
S
D
L
F
P
T
Cat
Felis silvestris
Mouse
Mus musculus
Q810L3
664
73853
S178
E
E
P
Q
P
S
T
S
T
S
D
L
L
P
T
Rat
Rattus norvegicus
NP_001009258
663
73935
S178
E
E
P
Q
P
S
T
S
T
S
D
L
L
P
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_415086
610
68316
Q164
I
E
S
A
S
V
E
Q
D
N
P
S
T
S
G
Frog
Xenopus laevis
Q5FWP4
625
70000
T167
S
T
S
S
L
F
S
T
P
T
T
S
A
I
P
Zebra Danio
Brachydanio rerio
A5WW08
637
71712
S171
Q
P
S
T
S
S
S
S
L
H
F
Y
N
M
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_799043
604
66879
K168
D
T
D
E
P
A
A
K
R
L
E
G
E
E
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_175188
466
53085
C58
S
L
E
K
H
E
W
C
R
I
T
K
N
L
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
90.5
81.7
N.A.
82.2
81.9
N.A.
N.A.
69.1
66.2
53.6
N.A.
N.A.
N.A.
N.A.
26.3
Protein Similarity:
100
N.A.
92.9
87.1
N.A.
88.5
88.2
N.A.
N.A.
77.5
76
68.6
N.A.
N.A.
N.A.
N.A.
44.1
P-Site Identity:
100
N.A.
26.6
26.6
N.A.
26.6
26.6
N.A.
N.A.
6.6
13.3
6.6
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
N.A.
33.3
33.3
N.A.
33.3
33.3
N.A.
N.A.
13.3
33.3
20
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
32.6
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
10
10
0
0
0
0
0
10
0
0
% A
% Cys:
10
0
10
0
0
0
0
10
0
0
0
0
0
0
0
% C
% Asp:
10
0
10
0
0
0
0
0
10
0
30
0
10
0
10
% D
% Glu:
30
40
20
20
10
20
10
0
0
0
10
0
10
10
0
% E
% Phe:
0
10
0
10
0
10
0
0
0
0
10
0
10
0
10
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
30
% G
% His:
0
0
0
0
10
0
0
0
0
10
0
0
0
0
0
% H
% Ile:
10
0
0
0
0
0
0
0
0
10
0
0
0
10
0
% I
% Lys:
0
0
0
10
0
0
0
10
0
0
0
10
0
0
0
% K
% Leu:
0
10
0
0
10
0
0
0
10
10
0
30
20
20
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
10
0
0
20
0
0
% N
% Pro:
0
10
30
0
50
0
20
0
20
0
10
0
0
30
20
% P
% Gln:
20
0
0
30
0
10
0
20
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
20
0
0
0
0
0
0
% R
% Ser:
20
0
30
10
20
40
20
50
0
50
0
40
0
20
0
% S
% Thr:
0
20
0
10
0
0
30
10
40
10
40
0
20
0
30
% T
% Val:
0
10
0
0
0
10
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _